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opioid-induced hyperalgesia

Etiology: - prolonged & escalating doses of opioids Pathology: - neuroexitatory effects of long-term opioid use Clinical manifestations: - worsening pain despite increase in opioid dosage - pain may be burning & or constant - other manifestations - cognitive slowing - hyperreflexia - myoclonus Management: - opioid dosage reduction in a monitored setting [1]

Specific

narcotic bowel syndrome; opioid-induced gastrointestinal hyperalgesia

General

hyperesthesia (hyperalgesia)

References

  1. Medical Knowledge Self Assessment Program (MKSAP) 18, American College of Physicians, Philadelphia 2018