oligodendrocyte-myelin glycoprotein (OMG OMGP)

Function: - cell adhesion molecule - role in myelination in the central nervous system - binds to RTN4R (putative) Structure: - O-glycosylated in its Ser/Thr-rich repeat domain (putative) - contains 8 LRR repeats (leucine-rich repeats) Compartment: cell membrane; lipid-anchor, GPI-anchor Expression: - oligodendrocytes & myelin of the central nervous system Note: - do not confuse with myelin-oligodendrocyte glycoprotein (MOG)

General

glypiated protein leucine-rich repeat-containing protein (LRRC) myelin protein

Properties

SIZE: entity length = 440 aa MW = 50 kD COMPARTMENT: myelin CELL-REGION: myelin sheath CELL: oligodendrocyte WITHIN: central nervous system MOTIF: signal sequence {1-24} leucine-rich repeat SITE: 33-54 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N45} leucine-rich repeat SITE: 55-77 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N61} leucine-rich repeat SITE: 78-100 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N103} leucine-rich repeat SITE: 122-145 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 146-168 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N152} leucine-rich repeat SITE: 170-189 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N176} N-glycosylation site {N189} leucine-rich repeat SITE: 190-213 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N192} leucine-rich repeat SITE: 217-228 MOTIF: leucine residue (SEVERAL) Ser/Thr-rich {229-270} MOTIF: N-glycosylation site {N234} Ser/Thr-rich {271-292} Ser/Thr-rich {293-335} Ser/Thr-rich {336-377} MOTIF: N-glycosylation site {N364} Ser/Thr-rich {378-416} MOTIF: N-glycosylation site {N389} glycosyl phosphatidylinositol [GPI] membrane anchor {N417} N-glycosylation site {N425}

Database Correlations

OMIM 164345 UniProt P23515 PFAM correlations Entrez Gene 4974 Kegg hsa:4974

References

UniProt :accession P23515