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fatty acid, omega-6

Unsaturation 6 carbons from the C terminus of the long-chain fatty acid. Dietary Sources: 1) see vegetable oil for omega-3 vs omega-6 composition of vegetable oils 2) animal fat (other than fish oil) tends to have a low content of omega-3 fatty acids Clinical significance: - American Heart Association has recommended >= 5-10% energy from omega-6 polyunsaturated fatty acids [2] - increased all-cause mortality from replacing saturated fat in diet with linoleic acid (omega-6) & increased cardiovascular mortality (RR = 1.70) [1] - omega-6 fatty acids as present in olive oil reduce oxidative stress & mitigate cognitive decline in older adults [3]

Related

fatty acid composition of brain vegetable oil

Specific

4,7,10,13,16-docosapentaenate; 4,7,10,13,16-docosapentaenoic acid (C22:5w6) 8,11,14-eicosatrienoate (dihomo gamma-linolenic acid) adrenate; adrenic acid; 7,10,13,16-docosatetraenoate [C22:4w6] arachidonate; arachidonic acid [C20:4w6, ARA] docosadienoate; docosadienoic acid (C22:2w6) gamma-linolenate; gamma-linolenic acid [C18:3w6] linoleate; linoleic acid [C18:2w6]

General

fatty acid, unsaturated

Properties

COMPARTMENT: membrane

References

  1. Ramsden CE et al Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis. BMJ 2013;346:e8707 PMID: 23386268 http://www.bmj.com/content/346/bmj.e8707 - Calder PC Old study sheds new light on the fatty acids and cardiovascular health debate. BMJ 2013;346:f493 PMID: 23386269 http://www.bmj.com/content/346/bmj.f493
  2. Harris WS et al Omega-6 Fatty Acids and Risk for Cardiovascular Disease: A Science Advisory From the American Heart Association Nutritional Subcommittee on the Council on Nutirion, Physical Activity, and Metabolism; Council on Cardiovascular Nursing; and Council on Epidemiology and Prevention. Circulation 2009 119:902-907 PMID: 19171857 http://circ.ahajournals.org/content/119/6/902.full.pdf
  3. Anderson P Dietary Fat Tied to Better Cognition in Older Adults. Medscape Feb 3, 2022 https://www.medscape.com/viewarticle/967806 - Liu D, Zhou L, Yang M et al Oxidative Stress Mediates the Association Between Dietary Fat Intake and Cognition in US Older Adults. Am J Geriatric Psychiatry 2022. Jan 14 PMID: 35151552 https://www.sciencedirect.com/science/article/abs/pii/S106474812200001X