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oxidized low-density lipoprotein receptor 1; Ox-LDL receptor 1; lectin-type oxidized LDL receptor 1; lectin-like oxidized LDL receptor 1; lectin-like oxLDL receptor 1; LOX-1; hLOX-1 (OLR1, LOX1)
Function:
1) mediates recognition, internalization & degradation of oxidized low density lipoprotein (oxLDL) by vascular endothelial cells
2) binding of oxLDL induces the activation of NF-kappa-B via
a) production of intracellular reactive oxygen
b) reduction of nitric oxide (NO) release
c) monocyte adhesion
d) apoptosis
3) receptor for the HSP70 protein
- antigen cross-presentation to naive T-cells in dendritic cells
4) leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation
5) receptor for
a) advanced glycation end products (AGE)
b) activated platelets
c) monocytes
d) apoptotic cells
e) Gram-negative & Gram-positive bacteria
6) interacts with HSP70
Structure:
- homodimer, disulfide-linked
- may form a hexamer
- N-glycosylated
- intrachain disulfide-bonds prevent N-glycosylation at some sites
- contains 1 C-type lectin domain; C-type lectin domain mediates the recognition & binding of oxLDL
- cytoplasmic region is required for subcellular sorting on the cell surface
Compartment: plasma membrane, a secreted form is likely
Expression:
1) expressed at high level in
a) endothelial cells
b) highly vascularized organs
- placenta, lung, liver, brain
c) aortic intima
d) bone marrow
e) spinal cord
e) surface of dendritic cells
2) widely expressed at intermediate & low level
3) induction by inflammatory cytokines
a) TNF-alpha, IFN-gamma, IL-6
b) pathological conditions
- hyperlipidemia, hypertension, diabetes mellitus
4) up-regulated in atherosclerotic lesions, by oxLDL, reactive oxygen species, fluid shear stress
Pathology:
1) binding of oxLDL induces pro-atherogenic cellular response
2) may amplify oxLDL-induced vascular dysfunction
3) defects in OLR1 may be a cause of:
a) susceptibility to myocardial infarction
b) susceptibility to Alzheimer disease (AD) (controversial)
Related
oxidized low density lipoprotein (oxidized LDL, oxLDL)
General
glycoprotein
low-density lipoprotein receptor; LDL receptor; apoB/E receptor (LDLR)
oligomerizing protein
Properties
CONFIGURATION: dimer
SIZE: MW = 31 kD
entity length = 273 aa
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {37-57}
Neck. {58-150}
MOTIF: coiled coil {64-123}
N-glycosylation site {N73}
N-glycosylation site {N139}
cysteine residue {C140}
MODIFICATION: cysteine residue {C-INTERCHAIN}
cysteine residue {C144}
MODIFICATION: cysteine residue {C155}
C-TYPE LECTIN {151-265}
MOTIF: cysteine residue {C155}
MODIFICATION: cysteine residue {C144}
cysteine residue {C172}
MODIFICATION: cysteine residue {C264}
cysteine residue {C243}
MODIFICATION: cysteine residue {C256}
cysteine residue {C256}
MODIFICATION: cysteine residue {C243}
cysteine residue {C264}
MODIFICATION: cysteine residue {C172}
Database Correlations
OMIM correlations
MORBIDMAP 602601
UniProt P78380
Pfam PF00059
Kegg hsa:4973
References
- UniProt :accession P78380
- OMIM :accession 602601
- Functional Glycomics gateway - Glycan binding
Note: Oxidized LDL receptor
http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Ctlect_249