Search
UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 110 kD subunit; O-GlcNAc transferase subunit p110; O-linked N-acetylglucosamine transferase 110 kD subunit (OGT)
Function:
- addition of nucleotide-activated sugars directly onto polypeptide through O-glycosidic linkage with the hydroxyl of Ser or Thr
- mediates O-glycosylation of MLL5
- protein modification; protein glycosylation
- heterotrimer of two 110 kD & one 70 kD subunits
- unknown if the 70 kD subunit is encoded by a separate gene or is the product of either of a proteolytic degradation or an alternative initiation of the 110 kD subunit (putative)
- interacts with ATXN10 (putative)
- component of the MLL5-L complex
- interacts with HCFC1
Structure:
- belongs to the O-GlcNAc transferase family
- contains 13 TPR repeats
Compartment: cytoplasm (putative), nucleus
Alternative splicing: named isoforms=3
Expression:
- highly expressed in pancreas
- lower expression in skeletal muscle, heart, brain & placenta
- present in trace amounts in lung & liver
General
glycoprotein
phosphoprotein
protein subunit
Properties
SIZE: entity length = 1046 aa
MW = 117 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S20}
tetratricopeptide repeat {21-54}
tetratricopeptide repeat {89-122}
tetratricopeptide repeat {123-156}
tetratricopeptide repeat {157-190}
tetratricopeptide repeat {191-224}
tetratricopeptide repeat {225-258}
tetratricopeptide repeat {259-292}
tetratricopeptide repeat {293-326}
tetratricopeptide repeat {327-360}
tetratricopeptide repeat {361-394}
tetratricopeptide repeat {395-428}
tetratricopeptide repeat {429-462}
tetratricopeptide repeat {463-473}
nuclear translocation signal {487-503}
Database Correlations
OMIM 300255
UniProt O15294
Pfam PF00515
Entrez Gene 8473
Kegg hsa:8473
References
- UniProt :accession O15294
- Functional glycomics gateway - GTase;
UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase
http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewglycoEnzyme.jsp?gbpId=gt_hum_554
Component-of
MLL5-L complex