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odevixibat (Bylvay)
Indications:
- treatment of pruritus in progressive familial intrahepatic cholestasis
Dosage:
- 40 ug/kg qAM
- after 3 months may increase in increments of 40 ug/kg/day up to 120 ug/kg/day if no improvement in pruritus
- maximum 6mg/day
Capsules: 0.2, 0.4, 0.6, 1.2 mg
Monitor:
- baseline & during treatment
- liver function tests (eg, ALT, AST, total bilirubin, & direct bilirubin
- serum fat-soluble vitamins levels
- INR
Adverse effects:
- diarrhea, including bloody diarrhea, hepatomegaly
Mechanism of action:
- selective inhibitor of the ileal bile acid transporter (IBAT)
General
gastrointestinal agent
enzyme inhibitor
References
- Wikipedia: Odevixibat
https://en.wikipedia.org/wiki/Odevixibat
- odevixibat (Rx)
Medscape
https://reference.medscape.com/drug/bylvay-odevixibat-4000172