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POU domain, class 2, transcription factor 2; lymphoid-restricted immunoglobulin octamer-binding protein NF-A2; octamer-binding protein 2; Oct-2; octamer-binding transcription factor 2; OTF-2 (POU2F2, OCT2, OTF2)
Function:
- transcription factor & DNA-binding protein
- specifically binds to the octamer motif 5'-ATTTGCAT-3'
- regulates transcription in a number of tissues
- activates immunoglobulin gene expression
- modulates transcription transactivation by NR3C1, AR & PGR
- isoform 5 activates the U2 small nuclear RNA (snRNA) promoter
- interacts with NR3C1, AR & PGR
Structure:
- belongs to the POU transcription factor family, class- 2 subfamily
- contains 1 homeobox DNA-binding domain
- contains 1 POU-specific domain
Compartment:
- cytoplasm (putative)
- nucleus
Alternative splicing: named isoforms=5
Expression:
- isoform 3 is B-cell specific
- isoform 5 is expressed in B-cells & the immunoglobulin- expressing T-cell line molt-4, but not in the T-cell line BW 5147
Related
OCT2 Ag in tissue
General
octamer transcription factor
phosphoprotein
Properties
SIZE: entity length = 479 aa
MW = 51 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: POU domain
SITE: 195-269
MOTIF: Ser phosphorylation site {S250}
homeodomain
SITE: 297-356
leucine zipper
SITE: 389-410
FOR-BINDING-VIA: leucine zipper
glycine-rich region {417-424}
Database Correlations
OMIM 164176
UniProt P09086
PFAM correlations
Entrez Gene 5452
Kegg hsa:5452
References
- Monuki ES, Kuhn R, Weinmaster G, Trapp BD, Lemke G.
Expression and activity of the POU transcription factor SCIP.
Science. 1990 Sep 14;249(4974):1300-3.
PMID: 1975954
- OMIM :accession 164176
- UniProt :accession P09086