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ocriplasmin
Indications:
- vitreomacular traction in adults, only if:
- an epiretinal membrane is not present &
- stage 2 full-thickness macular hole with diameter <= 400 uM &/or
- severe symptoms [NGC (NICE)]
Mechanism of action:
- recombinant truncated form of human plasmin
Specific
ocriplasmin ophthalmic (Jetrea)
General
recombinant protein; chimer
plasmin; fibrinolysin
References
- Stalmans P et al
Enzymatic Vitreolysis with Ocriplasmin for Vitreomacular
Traction and Macular Holes.
N Engl J Med 2012; 367:606-615
PMID: 22894573
http://www.nejm.org/doi/full/10.1056/NEJMoa1110823
Huang J et al
N Engl J Med 2012; 367:2052-2054
http://www.nejm.org/doi/full/10.1056/NEJMc1211068
- Jetrea
http://www.rxlist.com/jetrea-drug.htm