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occludin (OCLN)
Function:
- may play a role in the formation & regulation of the tight junction paracellular permeability barrier
- able to induce adhesion when expressed in cells lacking tight junctions
- phosphorylated upon DNA damage, probably by ATM or ATR
- interacts with TJP1/ZO1 & with VAPA
Structure:
- the C-terminal is cytoplasmic
a) important for interaction with ZO-1
b) sufficient for the tight junction localization
c) involved in the regulation of the permeability barrier function of the tight junction (putative)
- the first extracellular loop participates in an adhesive interaction belongs to the ELL/occludin family
- contains 1 MARVEL domain
Compartment:
- membrane, cell junction, tight junction
Expression:
- localized at tight junctions of both epithelial cells & endothelial cells
- highly expressed in kidney
- not detected in testis
General
membrane protein
phosphoprotein
Properties
SIZE: entity length = 522 aa
MW = 59 kD
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-66}
MARVEL {60-269}
MOTIF: transmembrane domain {67-89}
exoplasmic loop {90-135}
transmembrane domain {136-160}
cytoplasmic loop {161-170}
transmembrane domain {171-195}
exoplasmic loop {196-243}
transmembrane domain {244-265}
cytoplasmic domain {266-522}
MOTIF: Thr phosphorylation site {T305}
Ser phosphorylation site {S408}
coiled coil {426-489}
Database Correlations
OMIM 602876
UniProt Q16625
PFAM correlations
Entrez Gene 4950
Kegg hsa:4950
References
- UniProt :accession Q16625
- Wikipedia; Note: Occludin entry
http://en.wikipedia.org/wiki/Occludin