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leptin; obesity factor; obese protein (LEP, OB, OBS)

Function: - regulation of: a) body weight/fat metabolism b) hematopoiesis c) angiogenesis d) wound healing e) inflammatory & immune response f) bone mineral density (increases) Expression: - secreted by adipocytes - circadian rhythm; highest plasma levels at 2 AM Pathology: 1) leptin gene mutation associated with autosomal recessive obesity 2) higher plasma leptin associated with lower risk of AD [3]

Related

leptin receptor; LEP-R; OB receptor; OB-R; HuB219; CD295 (LEPR, DB, OBR) OB or LEP gene

Specific

Leptin Parenteral

General

adipokine

Properties

SIZE: entity length = 167 aa MW = 16 kD COMPARTMENT: extracellular compartment

Database Correlations

OMIM correlations MORBIDMAP 164160 UniProt P41159 LOCUS-LINK correlations Kegg hsa:3952

References

  1. Gerotological Society, Annual Meeting, Boston MA, Nov 2002
  2. OMIM :accession 164160
  3. Lieb W et al. Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging. JAMA 2009 Dec 16; 302:2565. PMID: 20009056
  4. UniProt :accession P41159
  5. R&D systems' cytokine mini-reviews: leptin http://www.rndsystems.com/molecule_detail.aspx?m=1773
  6. Wikipedia; Note: leptin entry http://en.wikipedia.org/wiki/leptin
  7. SeattleSNPs http://pga.gs.washington.edu/data/lep/