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ornithine decarboxylase antizyme 1; ODC-Az (OAZ1, OAZ)
Function:
- binds to, & destabilizes, ornithine decarboxylase which is then degraded
- also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter
- SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1
- forms a ternary complex with PSMB4 & SMAD1 before PSMB4 is incorporated into the 20S proteasome
Structure: belongs to the ODC antizyme family
Notes:
- a ribosomal frameshift occurs between the codons for Ser-68 & Asp-69
- an autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines
Related
antizyme inhibitor 1; AZI; ornithine decarboxylase antizyme inhibitor (AZIN1, OAZI, OAZIN)
ornithine decarboxylase 1
General
ornithine decarboxylase antizyme
Properties
SIZE: entity length = 228 aa
MW = 25 kD
Database Correlations
OMIM 601579
UniProt P54368
Pfam PF02100
Entrez Gene 4946
Kegg hsa:4946
References
- UniProt :accession P54368
- NIEHS-SNPs
http://egp.gs.washington.edu/data/oaz1/