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nystatin (Mycostatin, Nilstat, Nystop, Bio-statin)

Tradename: Mycostatin, Nilstat. Indications: 1) treatment of non-invasive, generally topical fungal infections 2) most active against Candidal yeast infections Dosage: - Oral agent: 4-6 mL PO swish + swallow QID. - Infants: 2 mL/dose, with 1 mL in each side of mouth. Solution: 100,000 units/mL Suspension (oral) 100,000 units/gram (60 mL). Tablet (oral): 500,000 units - Topical agent: Candidiasis: apply BID/TID Cream: 100,00 units/gram (15 g, 30 g) Ointment: 100,000 units/gram (15 g, 30 g) Powder: (topical) 100,000 units/gram (15 g) - Vaginal infections: 1 tab per vagina QD or BID Vaginal tablet: 100,000 units (15 & 30 boc with applicator) Troches: 200,000 units Pharmacokinetics: not absorbed orally or topically Adverse effects: 1) not common (1-10%) - nausea/vomiting, diarrhea, stomach pain 2) uncommon (< 1%) - hypersensitivity reactions Mechanism of action: 1) antifungal/antibiotic: 3 active components; A1, A2 & A3 2) obtained from Streptomyces 3) binds to membrane sterols resulting in increased permeability 4) fungistatic & fungicidal

Interactions

drug interactions

General

antifungal agent

Properties

MISC-INFO: elimination route FECES pregnancy-category B A safety in lactation ?

Database Correlations

PUBCHEM correlations

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  3. Kaiser Permanente Northern California Regional Drug Formulary, 1998

Component-of

cortisol/diphenhydramine/nystatin cortisol/diphenhydramine/nystatin/tetracycline diphenhydramine/lidocaine/nystatin neomycin/nystatin/thiostrepton/triamcinolone nystatin/triamcinolone (Mycolog II, Mycogen II, Tri-Statin II)