Contents

Search

Nurses' Health Study

1,091 NHS I participants (mean age, about 55) & 94,503 NHS II participants (mean age, about 36). Conclusions: 1) women taking at least 2 tablets of NSAIDs/week for 5 years or longer have a 20% lower risk of breast cancer [1] 2) long-terms aspirin, NSAIDs reduce risk of colon cancer [2] a) benefit seen after 10 years of use b) maximal benefit with > 2 tablets/day 3) higher plasma folate & vitamin B6 levels are associated with a lower risk of breast cancer [1] 4) coffee consumption NOT linked to increased risk of hypertension 5) cola consumption (diet or regular) linked to increased risk of hypertension 6) relative risk of breast cancer = 1.42 after 20 years of unapposed estrogen in women s/p hysterectomy

General

clinical trial

References

  1. Prescriber's Letter 10(5):28 2003
  2. Chan AT, Giovannucci EL, Meyerhardt JA, Schernhammer ES, Curhan GC, Fuchs CS. Long-term use of aspirin and nonsteroidal anti-inflammatory drugs and risk of colorectal cancer. JAMA. 2005 Aug 24;294(8):914-23. PMID: 16118381
  3. Winkelmayer WC et al, Habitual caffeine intake and the risk of hypertension in women. JAMA 2005 Nov 9; 294:2330 PMID: 16278361
  4. Stefanick ML et al Effects of conjugated equine estrogens on breast cancer and mammography screening in postmenopausal women with hysterectomy JAMA 2006; 295:1647 PMID: 16609086 - Chen WY et al, Unopposed estrogen therapy and the risk of invasive breast cancer Arch Intern Med 2006; 166:1027 PMID: 16682578