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nucleosome remodeling & histone deacetylation (NuRD) complex
Structure:
- subunits:
- HDAC core complex, MTA2, MBD2, MBD3, MTA1L1, CHD3 & CHD4
Related
NuRD complex (GO:0016581)
General
molecular complex
Properties
SUBUNITS: histone deacetylase core complex
metastasis-associated protein MTA2
COMPARTMENT: cell nucleus
MOTIF: BAH {1-144}
MOTIF: Ser phosphorylation site {S57}
ELM2 {145-256}
SANT {263-315}
Zn finger GATA-type
SITE: 367-394
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S433}
Ser phosphorylation site {S435}
Thr phosphorylation site {T505}
Thr phosphorylation site {T534}
Thr phosphorylation site {T540}
methyl-CpG-binding domain protein 2
COMPARTMENT: cell nucleus
MOTIF: glycine-rich region {6-140}
MOTIF: arginine-rich region {50-96}
MOTIF: arginine residue (SEVERAL)
MBD {145-213}
MOTIF: Ser phosphorylation site {S181}
Ser phosphorylation site {S407}
methyl-CpG-binding domain protein 3
COMPARTMENT: cell nucleus
MOTIF: MBD {1-72}
MOTIF: Ser phosphorylation site {S56}
coiled coil {216-245}
glutamate-rich region {272-281}
MOTIF: glutamate residue (SEVERAL)
metastasis-associated protein MTA2
COMPARTMENT: cell nucleus
MOTIF: BAH {1-144}
MOTIF: Ser phosphorylation site {S57}
ELM2 {145-256}
SANT {263-315}
Zn finger GATA-type
SITE: 367-394
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S433}
Ser phosphorylation site {S435}
Thr phosphorylation site {T505}
Thr phosphorylation site {T534}
Thr phosphorylation site {T540}
chromodomain-helicase-DNA-binding protein 3
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Ser phosphorylation site {S43}
alanine-rich region {206-221}
MOTIF: alanine residue (SEVERAL)
proline-rich region
SITE: 243-246
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S324}
lysine-rich region {355-358}
MOTIF: lysine residue (SEVERAL)
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 379-426
EFFECTOR-BOUND: Zn+2
glutamate-rich region {434-446}
MOTIF: glutamate residue (SEVERAL)
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 456-503
EFFECTOR-BOUND: Zn+2
chromodomain
NAME: chromodomain
SITE: 494-594
FOR-BINDING-OF: heterochromatin
chromodomain
NAME: chromodomain
SITE: 631-673
FOR-BINDING-OF: heterochromatin
lysine-rich region {697-703}
MOTIF: lysine residue (SEVERAL)
Ser phosphorylation site {S713}
helicase
NAME: helicase
SITE: 748-932
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 761-768
DEAD/H box
NAME: DEAD/H box
SITE: 883-886
Helicase C-terminal {1064-1229}
Ser phosphorylation site {S1361}
Ser phosphorylation site {S1364}
Ser phosphorylation site {S1367}
Ser phosphorylation site {S1549}
PCNT interaction {1566-1966}
MOTIF: Ser phosphorylation site {S1601}
Ser phosphorylation site {S1605}
chromodomain-helicase-DNA-binding protein 4
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: lysine-rich region {50-59}
MOTIF: lysine residue (SEVERAL)
glutamate-rich region {94-98}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S103}
lysine-rich region {114-119}
MOTIF: lysine residue (SEVERAL)
glutamate-rich region {134-138}
MOTIF: glutamate residue (SEVERAL)
alanine-rich region {227-235}
MOTIF: alanine residue (SEVERAL)
proline-rich region
SITE: 248-252
MOTIF: proline residue (SEVERAL)
lysine-rich region {350-354}
MOTIF: lysine residue (SEVERAL)
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 370-417
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S428}
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 449-496
EFFECTOR-BOUND: Zn+2
chromodomain
NAME: chromodomain
SITE: 494-594
FOR-BINDING-OF: heterochromatin
MOTIF: Ser phosphorylation site {S515}
Thr phosphorylation site {T517}
Thr phosphorylation site {T529}
Ser phosphorylation site {S531}
chromodomain
NAME: chromodomain
SITE: 622-697
FOR-BINDING-OF: heterochromatin
helicase
NAME: helicase
SITE: 738-922
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 751-758
DEAD/H box
NAME: DEAD/H box
SITE: 873-876
Helicase C-terminal {1054-1203}
glutamate-rich region {1294-1301}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S1308}
Ser phosphorylation site {S1349}
Ser phosphorylation site {S1370}
Ser phosphorylation site {S1531}
Ser phosphorylation site {S1535}
Ser phosphorylation site {S1537}
Thr phosphorylation site {T1540}
Thr phosphorylation site {T1542}
Thr phosphorylation site {T1545}
Thr phosphorylation site {T1549}
Thr phosphorylation site {T1553}
Ser phosphorylation site {S1570}
Ser phosphorylation site {S1576}
PCNT interaction {1577-1912}
MOTIF: Ser phosphorylation site {S1602}
glutamate-rich region {1665-1668}
MOTIF: glutamate residue (SEVERAL)
References
- UniProt :accession Q4LE39
Components
chromodomain-helicase-DNA-binding protein 3; CHD-3; ATP-dependent helicase CHD3; Mi-2 autoantigen 240 kD protein; Mi2-alpha; zinc finger helicase; hZFH (CHD3)
chromodomain-helicase-DNA-binding protein 4; CHD-4; ATP-dependent helicase CHD4; Mi-2 autoantigen 218 kD protein; Mi2-beta (CHD4)
histone deacetylase (HDAC) core complex
metastasis-associated protein MTA2; metastasis-associated 1-like 1; MTA1-L1 protein; p53 target protein in deacetylase complex (MTA2, MTA1L1, PID)
methyl-CpG-binding domain protein 2; DMTase; methyl-CpG-binding protein MBD2 (MBD2)
methyl-CpG-binding domain protein 3; methyl-CpG-binding protein MBD3 (MBD3)