NudC domain-containing protein 1 (chronic myelogenous leukemia tumor antigen 66, tumor antigen CML66, NUDCD1, CML66)

Structure: contains 1 CS domain Alternative splicing: named isoforms=3 Expression: - isoform 1 is detected in testis & heart dominant immunogenic isoform & is capable of eliciting a humoral response in individuals with a variety of solid tumors - isoform 2 is predominantly expressed in testis Pathology: - isoform 1 is specifically expressed in leukemias & a variety of solid tumor cell lines - expression of isoform 1 in a wide variety of malignancies as well as the presence of an immunogenic epitope suggest that it may be a suitable target for antigen-specific immunotherapy - isoform 2 is weakly expressed in tumor cells

Properties

GENERAL: uncharacterized protein SIZE: entity length = 583 aa MW = 67 kD FORM: NudC domain-containing protein 1 MOTIF: CS {273-361}

Database Correlations

OMIM 606109 UniProt Q96RS6 Pfam PF04969

References

UniProt :accession Q96RS6