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NUAK family SNF1-like kinase 2; omphalocele kinase 2; SNF1/AMP kinase-related kinase; SNARK (NUAK2, OMPHK2, SNARK)
Function:
1) stress-activated kinase involved in tolerance to glucose starvation
2) induces cell-cell detachment by increasing F-actin conversion to G-actin
3) protects cells from CD95-mediated apoptosis
4) able to phosphorylate Ser-464 of LATS1
5) activated by phosphorylation on Thr-208 by STK11 in complex with STRAD alpha & CAB39.
6) autophosphorylated in vitro
Cofactor: Mg+2
Structure:
- belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
- contains 1 protein kinase domain
Expression:
- expression induced by CD95 or TNF-alpha, via NF-kappa-B
Pathology:
- required for the increased motility & invasiveness of CD95- activated tumor cells
General
serine/threonine kinase
Properties
SIZE: entity length = 628 aa
MW = 70 kD
STATE: active state
MOTIF: kinase domain
SITE: 53-303
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 59-67
ATP-binding site
NAME: ATP-binding site
SITE: 81-81
aspartate residue {D175}
Thr phosphorylation site {T208}
Ser phosphorylation site {S212}
Ser phosphorylation site {S377}
Ser phosphorylation site {S386}
Ser phosphorylation site {S435}
Ser phosphorylation site {S462}
Ser phosphorylation site {S523}
Ser phosphorylation site {S540}
Ser phosphorylation site {S544}
Ser phosphorylation site {S547}
Ser phosphorylation site {S550}
Ser phosphorylation site {S553}
Ser phosphorylation site {S585}
Database Correlations
OMIM 608131
UniProt Q9H093
Pfam PF00069
Entrez Gene 81788
Kegg hsa:81788
ENZYME 2.7.11.1
References
UniProt :accession Q9H093