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netrin-1 (NTN1, NTN1L)

Function: - netrins control guidance of CNS commissural axons & peripheral motor axons - its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively - prevents initiation of apoptosis (receptor mediated) - role in tumorigenesis by regulating apoptosis - binds to its receptors; DCC, DSCAM, UNC5A, UNC5B, UNC5C & probably UNC5D Structure: - contains 3 laminin EGF-like domains - contains 1 laminin N-terminal domain - contains 1 NTR domain Compartment: - secreted, extracellular space, extracellular matrix (putative) Expression: - widely expressed in normal adult tissues - highest levels in heart, small intestine, colon, liver & prostate - reduced expression in brain tumors & neuroblastomas

General

netrin

Properties

SIZE: entity length = 604 aa MW = 68 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-24} Laminin N-terminal {47-284} MOTIF: N-glycosylation site {N95} N-glycosylation site {N116} cysteine residue {C119} MODIFICATION: cysteine residue {C152} N-glycosylation site {N131} cysteine residue {C152} MODIFICATION: cysteine residue {C119} EGF domain {285-340} MOTIF: cysteine residue {C285} MODIFICATION: cysteine residue {C294} cysteine residue {C287} MODIFICATION: cysteine residue {C304} cysteine residue {C294} MODIFICATION: cysteine residue {C285} cysteine residue {C304} MODIFICATION: cysteine residue {C287} cysteine residue {C306} MODIFICATION: cysteine residue {C315} cysteine residue {C315} MODIFICATION: cysteine residue {C306} cysteine residue {C318} MODIFICATION: cysteine residue {C338} cysteine residue {C338} MODIFICATION: cysteine residue {C318} EGF domain {341-403} MOTIF: cysteine residue {C341} MODIFICATION: cysteine residue {C350} cysteine residue {C343} MODIFICATION: cysteine residue {C368} cysteine residue {C350} MODIFICATION: cysteine residue {C341} cysteine residue {C368} MODIFICATION: cysteine residue {C343} cysteine residue {C371} MODIFICATION: cysteine residue {C380} cysteine residue {C380} MODIFICATION: cysteine residue {C371} cysteine residue {C383} MODIFICATION: cysteine residue {C401} cysteine residue {C401} MODIFICATION: cysteine residue {C383} EGF domain {404-453} MOTIF: cysteine residue {C404} MODIFICATION: cysteine residue {C416} cysteine residue {C406} MODIFICATION: cysteine residue {C423} cysteine residue {C416} MODIFICATION: cysteine residue {C404} N-glycosylation site {N417} cysteine residue {C423} MODIFICATION: cysteine residue {C406} cysteine residue {C425} MODIFICATION: cysteine residue {C434} cysteine residue {C434} MODIFICATION: cysteine residue {C425} cysteine residue {C437} MODIFICATION: cysteine residue {C451} cysteine residue {C451} MODIFICATION: cysteine residue {C437} NTR {472-601} MOTIF: cysteine residue {C472} MODIFICATION: cysteine residue {C544} cysteine residue {C491} MODIFICATION: cysteine residue {C601} Cell attachment site {530-532} cysteine residue {C544} MODIFICATION: cysteine residue {C472} cysteine residue {C601} MODIFICATION: cysteine residue {C491}

Database Correlations

OMIM 601614 UniProt O95631 PFAM correlations Entrez Gene 9423 Kegg hsa:9423

References

  1. UniProt :accession O95631
  2. Serafini T et al The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell. 1994 Aug 12;78(3):409-24. PMID: 8062384