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5'-nucleotidase domain-containing protein 3 (Grp94-neighboring nucleotidase, NT5DC3, GNN, TU12B1-TY)
Cofactor: binds 1 Mg+2 per subunit (putative)
Structure: belongs to the 5'(3')-deoxyribonucleotidase family
Alternative splicing: named isoforms=2
Expression:
- expressed in brain, placenta, skeletal muscle, pancreas, testis, uterus, & small intestine
Pathology:
- diminished function may contribute to the development &/or progression of pancreatic cancer
- expression was increased in 2 acute myeloid leukemia clusters
General
deoxyribonuclease (DNase)
Properties
SIZE: entity length = 548 aa
MW = 63 kD
MOTIF: alanine-rich region {4-7}
MOTIF: alanine residue (SEVERAL)
aspartate residue {D102}
Mg+2-binding site
SITE: 102-102
aspartate residue {D104}
Mg+2-binding site
SITE: 104-104
Substrate binding {251-259}
Mg+2-binding site
SITE: 389-389
Database Correlations
UniProt Q86UY8
Pfam PF05761
Kegg hsa:5155
References
UniProt :accession Q86UY8