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nonstructural protein 5A (NS5A)
Function:
- plays a key role in Hepatitis C virus RNA replication
Structure:
- zinc-binding
- proline-rich hydrophilic
- phosphoprotein
Pharmacology:
- NS5A inhibitor (velpatasvir) used in combination with sofosbuvir for treatment of hepatitis C infection
General
viral protein
Properties
MOTIF: phosphorylation site
proline-rich region
MOTIF: proline residue (SEVERAL)
Zn+2-binding site
References
- Wikipedia: NS5A
https://en.wikipedia.org/wiki/NS5A
- Orciari Herman A, Fairchild DG]
New Once-Daily Hepatitis C Pill Effective Across 6 Genotypes.
Physician's First Watch, Nov 16, 2015
David G. Fairchild, MD, MPH, Editor-in-Chief
Massachusetts Medical Society
http://www.jwatch.org
- Foster GR, Afdhal N, Roberts SK et al
Sofosbuvir and Velpatasvir for HCV Genotype 2 and 3 Infection.
N Eng J Med. November 17, 2015
PMID: 26575258
http://www.nejm.org/doi/full/10.1056/NEJMoa1512612
- Ward JW, Mermin JH
Simple, Effective, but Out of Reach? Public Health Implications
of HCV Drugs.
N Eng J Med. November 17, 2015
PMID: 26575359