nuclear receptor subfamily 2 group C member 2; orphan nuclear receptor TR4; testicular receptor 4; orphan nuclear receptor TAK1 (NR2C2, TAK1, TR4)

Function: - orphan nuclear receptor - may regulate gene expression during the late phase of spermatogenesis - interacts with NR2C2AP/TRA16 which represses the activity of NR2C2 Structure: - belongs to the nuclear hormone receptor family, NR2 subfamily - contains 1 nuclear receptor DNA-binding domain Compartment: nucleus (probable) Expression: - transiently repressed during the meiotic phase of spermatogenesis

General

nuclear hormone receptor NR2 subfamily phosphoprotein zinc finger protein

Properties

SIZE: entity length = 596 aa MW = 65 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S68} DNA-binding motif SITE: 114-189 MOTIF: Zn finger C4-type SITE: 117-137 EFFECTOR-BOUND: Zn+2 Zn finger C4-type SITE: 153-177 EFFECTOR-BOUND: Zn+2 Ser phosphorylation site {S219} Thr phosphorylation site {T224}

Database Correlations

OMIM 601426 UniProt P49116 PFAM correlations Kegg hsa:7182

References

UniProt :accession P49116