nuclear receptor subfamily 2 group C member 1; orphan nuclear receptor TR2; testicular receptor 2 (NR2C1, TR2)

Function: - orphan nuclear receptor - represses transcription & binds DNA as a homodimer - binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism - interacts with NRIP1 - directly interacts with HDAC3 & HDAC4 via the DNA-binding domain (putative) Structure: - homodimer - belongs to the nuclear hormone receptor family, NR2 subfamily - contains 1 nuclear receptor DNA-binding domain Compartment: nucleus (putative)

General

phosphoprotein steroid receptor zinc finger protein

Properties

SIZE: entity length = 483 aa MW = 53 kD COMPARTMENT: cell nucleus MOTIF: DNA-binding motif SITE: 110-185 MOTIF: Zn finger C4-type SITE: 113-133 EFFECTOR-BOUND: Zn+2 Zn finger C4-type SITE: 149-173 EFFECTOR-BOUND: Zn+2 Ser phosphorylation site {S215} Thr phosphorylation site {T220}

Database Correlations

OMIM 601529 UniProt P13056 PFAM correlations

References

UniProt :accession P13056