glutamate receptor epsilon or glutamate receptor, ionotropic NMDA 2 (GRIN2)

4 different subtypes (1-4 or NR2A-D).

Specific

glutamate receptor epsilon-1; N-methyl D-aspartate receptor subtype 2A; NMDAR2A; hNR2A; NR2A (GRIN2A, NMDAR2A) glutamate receptor epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; NR2B; N-methyl-D-aspartate receptor subunit 3; hNR3; NR3 (GRIN2B, NMDAR2B) glutamate receptor epsilon-3; N-methyl D-aspartate receptor subtype 2C; NMDAR2C; NR2C (GRIN2C NMDAR2C) glutamate receptor epsilon-4; N-methyl D-aspartate receptor subtype 2D; NMDAR2D; NR2D; EB11 (GRIN2D, NMDAR2D)

Properties

COMPARTMENT: plasma membrane MOTIF: exoplasmic domain {N-TERMINAL} MOTIF: glycosylation site cysteine residue {N_TERMINAL} MODIFICATION: cysteine residue {N_TERMINAL} cysteine residue {N_TERMINAL} MODIFICATION: cysteine residue {N_TERMINAL} ligand-binding site transmembrane domain {TM1} cytoplasmic loop MOTIF: allosteric site FOR-BINDING-OF: polyamine LOOP#: 1 transmembrane domain {TM2} MOTIF: Mg+2-binding site exoplasmic loop MOTIF: allosteric site FOR-BINDING-OF: glycine LOOP#: 1 transmembrane domain {TM3} cytoplasmic domain {C-TERMINAL} MOTIF: S/T phosphorylation site Tyr phosphorylation site PDZ recognition motif NAME: PDZ recognition motif SITE: C_terminus FOR-BINDING-VIA: PDZ domain

References

- Kutsuwada T, Kashiwabuchi N, Mori H, Sakimura K, Kushiya E, Araki K, Meguro H, Masaki H, Kumanishi T, Arakawa M, et al. Molecular diversity of the NMDA receptor channel. Nature. 1992 Jul 2;358(6381):36-41. PMID: 1377365