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Oxysterols receptor LXR-alpha; liver X receptor alpha; nuclear orphan receptor LXR-alpha; nuclear receptor subfamily 1 group H member 3 (NR1H3, LXRA)

Function: - ligands are oxysterols - LXR-alpha binds to RXR to form heterodimers which bind to & activate LXRE enhancer elements - interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRE enhancer elements - role in regulation of cholesterol homeostasis via oxysterols - heterodimer of LXRA & RXR Structure: - belongs to the nuclear hormone receptor family, NR1 subfamily - contains 1 nuclear receptor DNA-binding domain Compartment: nucleus (putative) Alternative splicing: named isoforms=2 Expression: - visceral organs specific expression - expressed in liver, kidney & intestine > spleen > adrenals - also expressed in adipose tissue, macrophages - induced by 9-cis retinoic acid (9CRA)

Related

LX response element (LXRE) oxysterol; hydroxysterol retinoid X receptor (RXR)

General

LX nuclear receptor (LXR, oxysterol receptor)

Properties

SIZE: entity length = 447 aa MW = 50 kD COMPARTMENT: cell nucleus MOTIF: DNA-binding motif SITE: 95-170 MOTIF: Zn finger C4-type SITE: 98-118 EFFECTOR-BOUND: Zn+2 Zn finger C4-type SITE: 134-158 EFFECTOR-BOUND: Zn+2 binding site SITE: 215-434 FOR-BINDING-OF: ligand

Database Correlations

OMIM 602423 UniProt Q13133 PFAM correlations Kegg hsa:1006

References

  1. UniProt :accession Q13133
  2. Laffitte BA et al LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes, Proc Natl Acad Sci USA 2001, 98:507 PMID: 11149950