nuclear receptor ROR-alpha; retinoid-related orphan receptor-alpha; nuclear receptor RZR-alpha; nuclear receptor subfamily 1 group F member 1 (RORA, NR1F1, RZRA)

Function: - orphan nuclear receptor - binds DNA as a monomer to hormone response elements (HRE) containing a single core motif half-site preceded by a short A-T-rich sequence - one isomer binds to the consensus sequence 5'-[AT][TA]A[AT][CGT]TAGGTCA-3' Structure: - monomer - belongs to the nuclear hormone receptor family, NR1 subfamily - contains 1 nuclear receptor DNA-binding domain Compartment: nucleus (probable) Alternative splicing: named isoforms=4; alpha-1,2,3,4

General

nuclear hormone receptor NR1 subfamily zinc finger protein

Properties

SIZE: entity length = 556 aa MW = 63 kD COMPARTMENT: cell nucleus MOTIF: Modulating {1-105} DNA-binding motif SITE: 106-171 MOTIF: Zn finger C4-type SITE: 106-126 EFFECTOR-BOUND: Zn+2 Zn finger C4-type SITE: 142-166 EFFECTOR-BOUND: Zn+2 Hinge {172-304} MOTIF: glutamine-rich region {199-202} MOTIF: glutamine residue (SEVERAL) binding site SITE: 305-556 FOR-BINDING-OF: ligand

Database Correlations

OMIM 600825 UniProt P35398 PFAM correlations Kegg hsa:6095

References

UniProt :accession P35398