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NPXY motif or coated-pit internalization signal

Asn-Pro-X-Tyr where X may be one of several amino acid residues Required for coated-pit internalization of receptor. It is thought to interact with adaptin/clathrin complex. The transcription factor Fe65 binds to the NPTY motif in the cytoplasmic domain of the amyloid precursor protein [3].

Related

amyloid beta A4 protein-binding family B member 1; protein Fe65 (APBB1 FE65 RIR) clathrin-coated pit HA2/AP2 adaptor complex

General

binding site internalization signal

Properties

NAME: NPXY motif

References

  1. Cantley LC, Auger KR, Carpenter C, Duckworth B, Graziani A, Kapeller R, Soltoff S. Oncogenes and signal transduction. Cell. 1991 Jan 25;64(2):281-302. Review. Erratum in: Cell 1991 May 31;65(5):following 914. PMID: 1846320
  2. Hollenberg MD. Structure-activity relationships for transmembrane signaling: the receptor's turn. FASEB J. 1991 Feb;5(2):178-86. Review. PMID: 1848518
  3. Cao X, Sudhof TC. A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science. 2001 Jul 6;293(5527):115-20. Erratum in: Science 2001 Aug 24;293(5534):1436. PMID: 11441186