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nuclear protein localization protein 4 homolog; protein NPL4 (NPLOC4, KIAA1499, NPL4)
Function:
1) component of NPLOC4-UFD1L-VCP complex
2) ubiquitin fusion protein degradation (UFD) pathway
3) heterodimer with UFD1L, the heterodimer binds ubiquitinated proteins & VCP
4) binds ubiquitinated proteins via its RanBP2-type zinc finger
Structure:
- belongs to the NPL4 family
- contains 1 RanBP2-type zinc finger
Compartment:
- cytoplasm, endoplasmic reticulum, nucleus
Alternative splicing: named isoforms=2
General
zinc finger protein
Properties
SIZE: MW = 68 kD
entity length = 607 aa
COMPARTMENT: cytoplasm
cell nucleus
endoplasmic reticulum
MOTIF: Zinc finger
NAME: Zinc finger
SITE: 579-607
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 606590
UniProt Q8TAT6
PFAM correlations
References
UniProt :accession Q8TAT6
Component-of
NPLOC4-UFD1L-VCP complex