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neutral protamine Hagedorn (NPH) insulin
Intermediate-acting insulin (see insulin parenteral). Longer-acting than regular insulin.
Dosage:
- generally QHS dosing
- also used in combination with regular insulin
Pharmacokinetics:
1) onset 1-3 hours
2) peak 4-10 hours
3) duration 10-18 hours
Notes:
- hypoglycemia & glycemic control no better with detemir or glargine than with neutral protamine Hagedorn insulin [2]
General
long-acting insulin
References
- Medical Knowledge Self Assessment Program (MKSAP) 17,
American College of Physicians, Philadelphia 2015
- Lipska KJ, Parker MM, Moffet HH, Huang ES, Karter AJ
Association of initiation of basal insulin analogs vs neutral
protamine Hagedorn insulin with hypoglycemia-related emergency
department visits or hospital admissions and with glycemic
control in patients with type 2 diabetes.
JAMA 2018 Jul 3; 320:53.
PMID: 29936529
https://jamanetwork.com/journals/jama/fullarticle/2685850
- Crowley MJ, Maciejewski ML.
Revisiting NPH insulin for type 2 diabetes: Is a step back
the path forward?
JAMA 2018 Jul 3; 320:38.
PMID: 29936528
https://jamanetwork.com/journals/jama/fullarticle/2685849
Component-of
neutral protamine hagedorn/regular insulin; NPH/regular insulin; insulin 70/30