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neuronal PAS domain-containing protein 3 (neuronal PAS3, member of PAS protein 6, basic-helix-loop-helix-PAS protein MOP6, NPAS3, MOP6)
Function:
- role in neurogenesis (putative)
- efficient DNA binding requires dimerization with another bHLH protein
Structure:
- contains 1 basic helix-loop-helix domain (bHLH)
- contains 1 PAC domain (PAS-associated C-terminal domain
- contains 2 PAS domains (PER-ARNT-SIM domains)
Compartment: nucleus
Alternative splicing: named isoforms=6
Expression: ubiquitously expressed in the adult brain
Pathology:
- may control regulatory pathways relevant to schizophrenia & to psychotic
- chromosomal translocation t(9;14)(q34;q13) involving NPAS3 is found in a family with schizophrenia
General
basic helix loop helix (bHLH) family transcription factor
Properties
SIZE: MW = 101 kD
entity length = 933 aa
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 52-68
helix-loop-helix
NAME: helix-loop-helix
SITE: 69-105
FOR-BINDING-VIA: helix-loop-helix
PAS domain {147-217}
serine-rich region {231-239}
MOTIF: serine residue (SEVERAL)
PAS domain {319-389}
PAC domain {363-406}
glycine-rich region {696-777}
Database Correlations
UniProt Q8IXF0
PFAM correlations
References
UniProt :accession Q8IXF0