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nitric oxide [NO] synthase

Nitric oxide synthases produce nitric oxide.

Related

nitric oxide (NO, endothelium derived relaxation factor {EDRF})

Specific

NO synthase-1 (calmodulin NO synthase, NADPH diaphorase, neuronal NO synthase, nNOS) NO synthase-2 (inducible, i-NOS) NO synthase-3 (endothelial NO synthase, NOS3, ENOS)

General

calmodulin binding protein oligomerizing protein oxidoreductase

Properties

CONFIGURATION: dimer MOTIF: cofactor-binding site COFACTOR-BOUND: 5,6,7-8-tetrahydrobiopterin calmodulin binding site EFFECTOR-BOUND: Ca+2 cofactor-binding site COFACTOR-BOUND: flavin mononucleotide heme-binding site COFACTOR-BOUND: heme{FE+2/FE+3} FOR-BINDING-OF: O2 cofactor-binding site COFACTOR-BOUND: flavin adenine dinucleotide

References

  1. Vincent SR, Hope BT. Neurons that say NO. Trends Neurosci. 1992 Mar;15(3):108-13. Review. PMID: 1373918
  2. Prince RC, Gunson DE. Rising interest in nitric oxide synthase. Trends Biochem Sci. 1993 Feb;18(2):35-6. Review. PMID: 7683828