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norfloxacin (Noroxin, Chibroxin)
Tradename: Noroxin.
Indications:
- bacterial infections due to susceptible organisms
- cystitis
- gastroenteritis
- traveler's diarrhea
- eye infection
- corneal ulcer [5]
Dosage: 400 PO BID.
Tabs: 400 mg. Ophthalmic agent: Tradename: Chibroxin. 1 drop every 1-6 hours (0.3%)
Pharmacokinetics:
- achieves poor serum concentrations
Antimicrobial activity:
Gram positive
- Staphylococcus aureus (MSSA) (+/-)
Gram negative
- Neisseria gonorrhoeae
- Moraxella catarrhalis
- Haemophilus influenzae
- Escherichia coli
- Klebsiella species
- Enterobacter species
- Serratia marcescens
- Proteus vulgaris
- Pseudomonas aeruginosa
- Haemophilus ducreyi
Drug interactions:
-> norfloxacin inhibits cyt P450 1A2
-> may increase levels of drugs metabolized by cyt P450 1A2
Interactions
drug interactions
drug adverse effects of fluoroquinolones
Related
cytochrome p450 1A2 (cytochrome P3-450, phenacetin deethylase, cytochrome p450-4, CYP1A2)
General
fluoroquinolone
Properties
INHIBITS: DNA gyrase
MISC-INFO: elimination route LIVER
KIDNEY
pregnancy-category C
safety in lactation ?
Database Correlations
PUBCHEM cid=4539
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Sanford Guide to antimicrobial therapy 1997
- Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998
- Prescriber's Letter 13(3): 2006
Cytochrome P450 drug interactions
Detail-Document#: 220233
(subscription needed) http://www.prescribersletter.com
- Deprecated Reference