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orphenadrine (Norflex)

Orphenadrine. Tradename: Norflex. Indications: - muscle spasm associated with acute painful musculoskeletal conditions Dosage: 1) 60 mg IV/IM BID 2) 100 mg PO BID Tabs: 100 mg. Injection: 30 mg/mL (2 mL) Adverse effects: 1) common (> 10%) - drowsiness, dizziness, blurred vision B2) less common (1-10%) - flushing of the face, tachycardia, syncope, rash, nausea/vomiting, constipation, decreased urination, weakness, nystagmus, increased intraocular pressure, nasal congestion 3) uncommon (< 1%) - hallucinations, aplastic anemia Laboratory: 1) orphenadrine in serum/plasma 2) methods: GLC

Interactions

drug adverse effects of H1 receptor antagonists

General

H1 receptor antagonist (antihistamine) skeletal muscle relaxant (tranquilizer)

Properties

MISC-INFO: elimination route LIVER KIDNEY therapeutic-range 50-200 NG/ML toxic-range >0.5 UG/ML >1.86 UMOL/L pregnancy-category C safety in lactation ?

Database Correlations

PUBCHEM correlations

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  3. Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995

Component-of

acetaminophen/orphenadrine aspirin/caffeine/citrate/orphenadrine aspirin/caffeine/orphenadrine (Norgesic)