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Nordic diltaizem trial (NORDIC)
10,881 patients age 50-74 with diastolic BP > 100 mm Hg randomized, open, blinded endpoint study
Treatment groups
1) diltiazem
2) beta-blocker plus diuretic
Endpoints: stroke, myocardial infarction, cardiovascular death
Analysis by intention to treat
Results:
1) primary endpoint occurred in 403 patients in diltiazem group and 400 patients in beta-blocker plus diuretic group
2) blood pressure lowered 20-23/19 mm Hg in both groups, slighty favoring beta-blocker diuretic group
General
hypertension clinical trials
References
Hannson L et al,
Randomized trial of effects of calcium antagonists compared
with diuretic and beta-blockers on cardiovascular morbidity
and mortality in hypertension: the Nordic Diltiazem (NORDIL)
study
Lancet 2000; 356:359
PMID: 10972367