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nonoxynol 9

A group of surface-acting agents used in spermicidal preparations such as contraceptive foams & diaphragm jellies. Vaginal agent available as foam, cream, or suppositories. Provides some protection against Chlamydia & gonorrhea. Does NOT provide adequate protection against HIV [2,5] or other STDs [5] Adverse effects: -> frequent use may cause genital or rectal lesions which may facilitate HIV transmission [2] Mechanism of action: -> surface active agent: disrupts sperm cell membrane [3]

General

spermicidal agent

Database Correlations

PUBCHEM cid=72385

References

  1. Stedman's Medical Dictionary 27th ed, Williams & Wilkins, Baltimore, 1999
  2. Prescriber's Letter 9(6):31 2002
  3. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
  4. Department of Veterans Affairs, VA National Formulary
  5. FDA MedWatch http://www.fda.gov/medwatch/safety/2007/safety07.htm#Nonoxynol