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non-enzymatic glycosylation (Maillard reaction)
- chronic hyperglycemia may result in non-enzymatic glycation of proteins with accumulation of AGE pigments
- these AGE pigments may accumulate in extracellular proteins with slow turnover, i.e collagen
- hemoglobin A1c is probably the best known example of non-enzymatic glycation.
Related
advanced glycation endproduct (AGE) pigment
General
catabolic pathway
References
- Principles of Geriatric Medicine & Gerontology, 4th edition,
Hazzard WR et al, eds, McGraw Hill, New York, 1999, pg 999
- Wikipedia: Maillard reaction
https://en.wikipedia.org/wiki/Maillard_reaction