Contents

Search

neurite outgrowth inhibitor Nogo (reticulon-4, Nogo protein, Foocen, neuroendocrine-specific protein, NSP, neuroendocrine-specific protein C, RTN-x, reticulon-5, RTN4, KIAA0886, My043, SP1507)

Function: 1) inhibitory myelin protein; member of reticulon family 2) inhibits axonal extension/regeneration (both in restriction of axonal regeneration after injury & in structural plasticity in CNS) 3) isoform 2 reduces the anti-apoptotic activity of Bcl-xl & Bcl-2 4) binds to RTN4R 5) interacts with Bcl-xl & Bcl-2 6) Nogo-A (full length) has strongest inhibitory activity in culture Compartment: endoplasmic reticulum Alternative splicing: isoforms: at least 4; - Nogo-A, Nogo-B & Nogo-C Expression: - isoform 1 expressed in brain & testis, weakly in heart & skeletal muscle - isoform 2 widely expressed except for liver - isoform 3 expressed in brain, skeletal muscle, adipocytes - isoform 4 is testis-specific - Nogo-A (full length) is highly expressed in oligodendrocytes but not Schwann cells

Interactions

molecular events

Related

reticulon-4 receptor-like 1 (Nogo-66 receptor homolog 2, Nogo-66 receptor-related protein 3, NgR3, Nogo receptor-like 2, RTN4RL1, NGRH2, NGRL2) reticulon-4 receptor-like 2 (Nogo-66 receptor homolog 2, Nogo-66 receptor-related protein 2, NgR2, Nogo receptor-like 3, RTN4RL2, NGRH1, NGRL3) reticulon-4-interacting protein 1 (NOGO-interacting mitochondrial protein, RTN4IP1, NIMP)

General

phosphoprotein reticulon (neuroendocrine-specific protein-like, NSP-like protein, NSPL, RTN)

Properties

SIZE: MW = 130 kD entity length = 1192 aa COMPARTMENT: endoplasmic reticulum MOTIF: cytoplasmic domain {1-1038} MOTIF: glutamate-rich region {30-47} MOTIF: glutamate residue (SEVERAL) proline-rich region SITE: 143-148 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S860} Ser phosphorylation site {S863} transmembrane domain {1019-1039} exoplasmic loop {1040-1133} transmembrane domain {1134-1154} cytoplasmic domain {1155-1192}

Database Correlations

OMIM 604475 UniProt Q9NQC3 Pfam PF02453 Entrez Gene 57142 Kegg hsa:57142

References

  1. Goldberg JL & Barnes BA Nogo in nerve regeneration. Nature 403:369-70, 2000 PMID: 10667770
  2. GrandPre T et al Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. Nature 403:439-44, 2000 PMID: 10667797
  3. Chen MS et al Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 403:434-9, 2000 PMID: 10667796
  4. Prihjha R et al Inhibitor of neurite outgrowth in humans. Nature 403:383-4, 2000 PMID: 10667780
  5. UniProt :accession Q9NQC3
  6. SHMPD; Singapore human mutation and polymorphism database http://shmpd.bii.a-star.edu.sg/gene.php?genestart=R&genename=RTN4+%40+NOGO
  7. Protein Spotlight; Nerve regrowth: nipped by a no-go Issue 69 of April 2006 http://www.expasy.org/spotlight/back_issues/sptlt069.shtml
  8. Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/RTN4ID42182ch2p16.html

Component-of

molecular complex