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nodal homolog (NODAL)
Function:
- essential for mesoderm formation & axial patterning during embryonic development (putative)
Structure:
- homodimer; disulfide-linked (putative)
- belongs to the TGF-beta family
Compartment: secreted (putative)
Pathology:
- defects in NODAL are the cause of visceral heterotaxy autosomal type 5
General
cytokine
glycoprotein
TGF-beta family protein
Properties
SIZE: entity length = 347 aa
MW = 40 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-26}
N-glycosylation site {N72}
N-glycosylation site {N199}
cysteine residue {C247}
MODIFICATION: cysteine residue {C313}
cysteine residue {C276}
MODIFICATION: cysteine residue {C344}
cysteine residue {C280}
MODIFICATION: cysteine residue {C346}
cysteine residue {C312}
MODIFICATION: cysteine residue {C-INTERCHAIN}
cysteine residue {C313}
MODIFICATION: cysteine residue {C247}
cysteine residue {C344}
MODIFICATION: cysteine residue {C276}
cysteine residue {C346}
MODIFICATION: cysteine residue {C280}
Database Correlations
OMIM correlations
UniProt Q96S42
PFAM correlations
Entrez Gene 4838
Kegg hsa:4838
References
UniProt :accession Q96S42