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NO synthase-2 (inducible, i-NOS)

Nitric oxide synthases produce nitric oxide.

Related

nitric oxide (NO, endothelium derived relaxation factor {EDRF})

Specific

NO synthase-2A (macrophage NO synthase, inducible NO synthase, hepatocyte NOS, NOS2A) NO synthase-2B (inducible, NOS2B) NO synthase-2C (inducible, NOS2C) NO synthase-2D (inducible)

General

nitric oxide [NO] synthase

Properties

CONFIGURATION: dimer MOTIF: cofactor-binding site COFACTOR-BOUND: 5,6,7-8-tetrahydrobiopterin calmodulin binding site EFFECTOR-BOUND: Ca+2 cofactor-binding site COFACTOR-BOUND: flavin mononucleotide heme-binding site COFACTOR-BOUND: heme{FE+2/FE+3} FOR-BINDING-OF: O2 cofactor-binding site COFACTOR-BOUND: flavin adenine dinucleotide

References

  1. Snyder SH, Bredt DS. Nitric oxide as a neuronal messenger. Trends Pharmacol Sci. 1991 Apr;12(4):125-8. Review. PMID: 1712138
  2. Prince RC, Gunson DE. Rising interest in nitric oxide synthase. Trends Biochem Sci. 1993 Feb;18(2):35-6. Review. PMID: 7683828