60S ribosomal export protein NMD3 (hNMD3, NMD3)

Function: - acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit - found in a 60S ribosomal subunit export complex with RAN & XPO1 - interacts with XPO1 - associates with the 60S ribosomal subunit Structure: belongs to the NMD3 family Compartment: - cytoplasm, nucleus, nucleoplasm, nucleus, nucleolus - shuttles between the nucleus/nucleolus & the cytoplasm in a XPO1/CRM1-dependent manner

Properties

SIZE: entity length = 503 aa MW = 58 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: nucleolar localization signal {405-422} Necessary for the nuclear export of the 60S ribosomal subunit {425-503} MOTIF: Ser phosphorylation site {S468} Thr phosphorylation site {T470} nuclear export signal {480-489}

Database Correlations

UniProt Q96D46 Pfam PF04981

References

UniProt :accession Q96D46