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NF-kappa-B inhibitor-interacting Ras-like protein 2; I-kappa-B-interacting Ras-like protein 2; Kappa B-Ras protein 2; KappaB-Ras2 (NKIRAS2 KBRAS2)
Atypical ras-like protein
Function:
1) regulates NF-kappa-B activity
2) inhibits degradation of NFKBIB
3) inhibits phosphorylation of NFKBIB (putative)
4) inhibits nuclear localization of RELA NF-kappa-B subunit
5) both GTP- & GDP-bound forms block phosphorylation of NFKBIB
6) interacts with PEST domain in both NFKBIA & NFKBIB in vitro
7) probably only interacts with NFKBIB in vivo [2]
Structure:
- unlike other ras family proteins, conserved Gly & Gln in positions 13 & 65 are replaced by Leu in KBRAS1 & KBRAS2
- KBRAS1 & KBRAS2 resemble constitutively active, oncogenic forms of Ras
- belongs to the small GTPase superfamily, Ras family, KappaB-Ras subfamily
Compartment:
- cytoplasm
Alternative splicing: named isoforms=2
Expression:
- widely expressed
General
ras subfamily protein
Properties
SIZE: entity length = 191 aa
MW = 22 kD
COMPARTMENT: cytoplasm
MOTIF: binding site
FOR-BINDING-OF: protein kinase
binding site
FOR-BINDING-OF: ras GTPase activator protein
P-loop
FOR-BINDING-OF: guanosine triphosphate
guanosine diphosphate
Small GTPase-like {1-191}
MOTIF: GTP-binding site
SITE: 11-18
Effector region {35-43}
GTP-binding site
SITE: 61-65
GTP-binding site
SITE: 120-123
CaaX motif
SITE: C-TERMINUS
QUALITIES: AAX-TRUNCATED
CARBOXYMETHYLATED
EFFECTOR-BOUND: farnesyl
BOUND-VIA: cysteine residue
References
- Fenwick C et al.
A subclass of Ras proteins that regulate the degradation of
IkappaB.
Science 287:869-73, 2000
PMID: 10657303
- UniProt :accession Q9NYR9
Databases & Figures
OMIM 604497
UniProt Q9NYR9
Pfam PF00071
Entrez Gene 28511
Kegg hsa:28511
TNFR/IL1R1/CD28/TCR-CD3 -> NF kappa B