homeobox protein Nkx-6.1; homeobox protein NK-6 homolog A (NKX6-1, NKX6A)

Function: - transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes involved in transcriptional regulation in islet beta cells - binds to the insulin promoter & is involved in regulation of the insulin gene - together with NKX2-2 & IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube - belongs to class II proteins of neuronal progenitor factors, which are induced by SHH signals Structure: - the C-terminal domain contributes to sequence-specific DNA-binding (putative) - contains 1 homeobox DNA-binding domain Compartment: nucleus (probable) Expression: pancreatic beta cells

Properties

SIZE: entity length = 367 aa MW = 38 kD COMPARTMENT: cell nucleus MOTIF: serine-rich region {49-61} MOTIF: serine residue (SEVERAL) Repressor domain {102-268} MOTIF: serine-rich region {119-135} MOTIF: serine residue (SEVERAL) alanine-rich region {136-150} MOTIF: alanine residue (SEVERAL) proline-rich region SITE: 168-173 MOTIF: proline residue (SEVERAL) homeodomain SITE: 236-295 DNA-binding motif SITE: 306-367 MOTIF: glycine-rich region {351-355}

Database Correlations

OMIM 602563 UniProt P78426 Pfam PF00046 Entrez Gene 4825 Kegg hsa:4825

References

UniProt :accession P78426