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nisoldipine (Sular)

Tradename: Sular. Dosage: start 20 mg PO QD, max 60 mg QD Tabs: 10, 20, 30, 40 mg Pharmacokinetics: -> metabolized in the liver by cyt P450 3A4 Drug interactions: 1) any drug that inhibits cyt P450 3A4 may increase levels of nisoldipine 2) any drug that induces cyt P450 3A4 may diminish levels of nisoldipine

Interactions

drug interactions drug adverse effects (more general classes)

Related

cytochrome P450 3A4 (cytochrome P450 C3, nifedipine oxidase, P450-PCN1, NF-25, CYP3A4)

General

calcium channel blocker (CCB) dihydropyridine

Properties

MISC-INFO: elimination route LIVER pregnancy-category C safety in lactation ?

Database Correlations

PUBCHEM cid=4499

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Tarascon Pharmacopoeia, 2001
  3. Prescriber's Letter 13(3): 2006 Cytochrome P450 drug interactions Detail-Document#: 220233 (subscription needed) http://www.prescribersletter.com