nifurtimox (Lampit)

Indications: Chagas disease (Trypanosoma cruzi) 1) 8-10 mg/kg/day for adults 2) 12.5-15 mg/kg/day for adolescents 3) 15-20 mg/kg/day for children ages 1-10 years 4) doses given orally, divided QID 5) therapy should be continued to 90-120 days 6) available from CDC (707 639-3670) Adverse effects: 1) abdominal pain 2) anorexia 3) nausea/vomiting 4) weight loss 5) neurologic manifestations: a) restlessness b) disorientation c) insomnia d) twitching e) paresthesia f) polyneuritis g) seizures 6) symptoms, generally resolve when dosage is reduced or therapy is discontinued

References

Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 1194