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nicotinamide phosphoribosyltransferase (NAmPRTase, Nampt, pre-B cell-enhancing factor, pre-B-cell colony-enhancing actor 1, visfatin, NAMPT, PBEF, PBEF1)
Function:
1) catalyzes condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD
2) rate limiting component in the mammalian NAD biosynthesis
Nicotinamide D-ribonucleotide + diphosphate
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
Compartment: cytoplasm
Alternative splicing: named isoforms=2
Expression:
- expressed in bone marrow, liver, muscle > heart, placenta, lung, kidney
Notes:
- originally thought to be a cytokine acting on early B-lineage precursor cells, by enhancing the effect of IL-7 & SCF on pre-B-cell colony formation
General
phosphoribosyltransferase
Properties
SIZE: MW = 56 kD
entity length = 491 aa
COMPARTMENT: cytoplasm
MOTIF: Tyr phosphorylation site {Y188}
Database Correlations
OMIM 608764
UniProt P43490
Pfam PF04095
ENZYME 2.4.2.12
References
UniProt :accession P43490