H/ACA ribonucleoprotein complex subunit 2 (nucleolar protein family A member 2, snoRNP protein NHP2, NOLA2, NHP2, HSPC286)

Function: 1) required for ribosome biogenesis & telomere maintenance 2) component of H/ACA small nucleolar ribonucleoprotein complex (H/ACA snoRNP complex) 3) may be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. 4) associates with NOLC1/NOPP140 Structure: belongs to the ribosomal protein L7Ae family Compartment: - nucleus, nucleolus, Cajal body - localized to Cajal bodies (coiled bodies) Expression: - expressed in brain, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus > liver - transcript peaks at G1/S transition

Properties

SIZE: MW = 17 kD entity length = 153 aa COMPARTMENT: cell nucleus

Database Correlations

OMIM 606470 MORBIDMAP 606470 UniProt Q9NX24 Pfam PF01248

References

UniProt :accession Q9NX24