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NGLY1-SAKS1-AMFR-VCP-RAD23B complex
Function:
- complex required to couple retrotransloaction, ubiquitination, deglycosylation & proteasome-mediated degradation of misfolded proteins
Structure:
- consists of: NGLY1, SAKS1, AMFR, VCP & RAD23B
Compartment: endoplasmic reticulum
General
molecular complex
Properties
SUBUNITS: peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
COMPARTMENT: cytoplasm
MOTIF: PUB {30-91}
Zn+2-binding site
SITE: 250-250
Zn+2-binding site
SITE: 253-253
Zn+2-binding site
SITE: 283-283
Zn+2-binding site
SITE: 286-286
cysteine residue {C309}
histidine residue {H336}
aspartate residue {D353}
PAW {487-579}
SAPK substrate protein 1
COMPARTMENT: cytoplasm
MOTIF: UBA domain {1-42}
coiled coil {87-172}
Ser phosphorylation site {S200}
UBX {211-293}
autocrine motility factor receptor
COMPARTMENT: endoplasmic reticulum
MOTIF: transmembrane domain {82-102}
transmembrane domain {122-142}
transmembrane domain {145-165}
transmembrane domain {186-206}
transmembrane domain {215-235}
transmembrane domain {276-296}
RING-finger {341-379}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
transmembrane domain {429-449}
CUE {456-498}
valosin-containing protein
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S7}
ATP-binding site
NAME: ATP-binding site
SITE: 245-252
ATP-binding site
NAME: ATP-binding site
SITE: 518-525
Ser phosphorylation site {S702}
Ser phosphorylation site {S705}
Ser phosphorylation site {S784}
Tyr phosphorylation site {Y805}
UV excision repair protein RAD23 homolog B
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Ubiquitin-like {1-79}
threonine-rich region {103-106}
MOTIF: threonine residue (SEVERAL)
Thr phosphorylation site {T155}
Ser phosphorylation site {S160}
UBA 1 {188-228}
alanine-rich region {254-260}
MOTIF: alanine residue (SEVERAL)
threonine-rich region {261-269}
MOTIF: threonine residue (SEVERAL)
STI1 {274-317}
glycine-rich region {336-348}
UBA 2 {364-404}
References
UniProt :accession Q9UGP8
Components
autocrine motility factor receptor (AMF receptor, gp78, AMFR)
peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (PNgase, hPNGase, Peptide:N-glycanase, N-glycanase 1, NGLY1, PNG1)
SAPK substrate protein 1; UBA/UBX 33.3 kDa protein (SAKS1, UBXN1)
UV excision repair protein RAD23 homolog B; HR23B; hHR23B; XP-C repair-complementing complex 58 kD protein; p58 (RAD23B)
valosin-containing protein; transitional endoplasmic reticulum ATPase; TER ATPase; 15S Mg+2-ATPase p97 subunit (VCP)