nerve growth factor [NGF] receptor (high affinity)

high affinity NGF receptor formed by the association or p75NGFR with NTRK1

General

cell surface receptor molecular complex

Properties

COMPARTMENT: plasma membrane MOTIF: ligand-binding site transmembrane domain SUBUNITS: p75 NGFR MOTIF: signal sequence {1-28} TNFR-Cys {31-64} MOTIF: cysteine residue {C32} MODIFICATION: cysteine residue {C43} cysteine residue {C43} MODIFICATION: cysteine residue {C32} cysteine residue {C44} MODIFICATION: cysteine residue {C57} cysteine residue {C47} MODIFICATION: cysteine residue {C64} cysteine residue {C57} MODIFICATION: cysteine residue {C44} N-glycosylation site {N60} cysteine residue {C64} MODIFICATION: cysteine residue {C47} TNFR-Cys {66-107} MOTIF: cysteine residue {C67} MODIFICATION: cysteine residue {C83} cysteine residue {C83} MODIFICATION: cysteine residue {C67} cysteine residue {C86} MODIFICATION: cysteine residue {C99} cysteine residue {C89} MODIFICATION: cysteine residue {C107} cysteine residue {C99} MODIFICATION: cysteine residue {C86} cysteine residue {C107} MODIFICATION: cysteine residue {C89} TNFR-Cys {108-146} MOTIF: cysteine residue {C109} MODIFICATION: cysteine residue {C122} cysteine residue {C122} MODIFICATION: cysteine residue {C109} cysteine residue {C125} MODIFICATION: cysteine residue {C138} cysteine residue {C128} MODIFICATION: cysteine residue {C146} cysteine residue {C138} MODIFICATION: cysteine residue {C125} cysteine residue {C146} MODIFICATION: cysteine residue {C128} TNFR-Cys {148-188} MOTIF: cysteine residue {C149} MODIFICATION: cysteine residue {C164} cysteine residue {C164} MODIFICATION: cysteine residue {C149} cysteine residue {C167} MODIFICATION: cysteine residue {C180} cysteine residue {C170} MODIFICATION: cysteine residue {C188} cysteine residue {C180} MODIFICATION: cysteine residue {C167} cysteine residue {C188} MODIFICATION: cysteine residue {C170} threonine-rich region {197-248} MOTIF: threonine residue (SEVERAL) transmembrane domain {251-272} Mediates interaction with ARMS {326-341} death domain NAME: death domain SITE: 344-421 Ntrk1 MISC-INFO: Kd [NGF] 10 PM

References

Hempstead et al Nature 350:678 1991