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nerve growth factor [NGF]-beta (NGFB)
Function:
- contains all growth promoting activity of 7S NGF (see 7S NGF)
Structure: homodimer belongs to the NGF-beta family
Compartment: secreted
Pathology:
- defects in NGFB are the cause of hereditary sensory & autonomic neuropathy type 5
Related
gene
Specific
nerve growth factor topical (NGF topical)
General
oligomerizing protein
protein subunit
Properties
CONFIGURATION: dimer
SIZE: entity length = 241 aa
MW = 27 kD
MOTIF: signal sequence {1-18}
N-glycosylation site {N69}
Ser phosphorylation site {S84}
N-glycosylation site {N114}
cysteine residue {C136}
MODIFICATION: cysteine residue {C201}
cysteine residue {C179}
MODIFICATION: cysteine residue {C229}
cysteine residue {C189}
MODIFICATION: cysteine residue {C231}
cysteine residue {C201}
MODIFICATION: cysteine residue {C136}
cysteine residue {C229}
MODIFICATION: cysteine residue {C179}
cysteine residue {C231}
MODIFICATION: cysteine residue {C189}
Database Correlations
OMIM correlations
MORBIDMAP 162030
UniProt P01138
Pfam PF00243
KEGG correlations
References
- OMIM :accession 162030
- Bradshaw et al TIBS 18:48 1993
- Wikipedia; nerve growth factor entry
http://en.wikipedia.org/wiki/nerve_growth_factor
- UniProt :accession P01138
Component-of
7S nerve growth factor (7S NGF)