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NF-kappaB inhibitor epsilon; NF-kappa-BIE; I-kappa-B-epsilon; IkappaBepsilon; IkB-epsilon; IkB-E (NFKBIE, IKBE)
Function:
- inhibits NF-kappa-B by complexing with & trapping it in the cytoplasm
- inhibits DNA-binding of NF-kappa-B p50/NF-kappa-B p65 & p50-c-Rel complexes
- interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit & NFKB2 nuclear factor NF-kappa-B p52 subunit
- Ser phosphorylated; followed by proteasome-dependent degradation
Structure:
- belongs to the NF-kappa-B inhibitor family
- contains 6 ANK repeats
Compartment: cytoplasm (putative)
Expression:
- highly expressed in spleen, testis & lung, followed by kidney, pancreas, heart, placenta & brain
- also expressed in granulocytes & macrophages
General
human longevity protein
IKB protein
phosphoprotein
Properties
SIZE: entity length = 500 aa
MW = 53 kD
COMPARTMENT: cytoplasm
MOTIF: Ser phosphorylation site {S157}
Ser phosphorylation site {S161}
ankyrin repeat
NAME: ankyrin repeat
SITE: 258-291
ankyrin repeat
NAME: ankyrin repeat
SITE: 293-322
ankyrin repeat
NAME: ankyrin repeat
SITE: 326-355
ankyrin repeat
NAME: ankyrin repeat
SITE: 369-398
ankyrin repeat
NAME: ankyrin repeat
SITE: 403-432
ankyrin repeat
NAME: ankyrin repeat
SITE: 436-465
Database Correlations
OMIM 604548
UniProt O00221
Pfam PF00023
Entrez Gene 4794
Kegg hsa:4794
References
- Entrez Gene :accession 4794
- UniProt :accession O00221