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transcription factor NF-E2 45 kD subunit; nuclear factor erythroid-derived 2 45 kD subunit; p45 NF-E2; leucine zipper protein NF-E2 (NFE2)
Function:
- required for activity at the locus control region (LCR) upstream of the globin gene complexes
- requires p18 NF-E2 for binding to the NF-E2 motif
- may play a role in all aspects of hemoglobin production: globin synthesis, heme synthesis, & the procurement of iron
- interacts with MLL2; leading to activate transcription of the beta-globin locus (putative)
- heterodimer of p45 NF-E2 & p18 NF-E2
Structure:
- belongs to the bZIP family, CNC subfamily
- contains 1 bZIP domain
Compartment: nucleus
Expression:
- expressed in hematopoietic cells
- also expressed in colon & testis
General
basic leucine zipper (bZIP) family protein
Properties
SIZE: MW = 41 kD
entity length = 373 aa
COMPARTMENT: cell nucleus
MOTIF: proline residue {59-62} (4)
proline residue {77-82} (6)
bZIP domain
MOTIF: basic DNA-binding motif
leucine zipper
FOR-BINDING-VIA: leucine zipper
FOR-BINDING-OF: DNA motif
FOR-BINDING-VIA: leucine zipper
DNA-binding motif
SITE: 268-287
leucine zipper
SITE: 294-339
FOR-BINDING-VIA: leucine zipper
Database Correlations
OMIM 601490
UniProt Q16621
Pfam PF00170
Kegg hsa:4778
References
- Andrews NC, Erdjument-Bromage H, Davidson MB, Tempst P,
Orkin SH.
Erythroid transcription factor NF-E2 is a haematopoietic-
specific basic-leucine zipper protein.
Nature. 1993 Apr 22;362(6422):722-8.
PMID: 8469283
- SeattleSNPs
http://pga.gs.washington.edu/data/nfe2/
- UniProt :accession Q16621
Component-of
erythroid-restricted nuclear factor E2