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New Delhi metallo-beta-lactamase 1 (NDM-1)
Epidemiology:
- isolated from patients in India & Pakistan
- isolated from patients in the US in 2010; all received medical care in India [3]
Genetics:
- encoded on a gene carried by both bacterial chromosomes & plasmids from E coli & Klebsiella pneumonia
Pharmacology:
- confers resistance to carbapenems
- bacteria with NDM-1 appear to be sensitive to colistin & tigecycline
Clinical significance:
- carbapenem-resistant Klebsiella pneumoniae & other similarly resistant Enterobacteriaceae are resistant to most antimicrobial drugs, & are frequently fatal [2]
General
bacterial protein
beta lactamase
Properties
MOTIF: active site
References
- Kumarasamy KK et al
Emergence of a new antibiotic resistance mechanism in India,
Pakistan, and the UK: a molecular, biological, and
epidemiological study.
The Lancet Infectious Diseases, Early Online Publication,
11 August 2010
PMID: 20705517
http://www.thelancet.com/journals/laninf/article/PIIS1473-3099%2810%2970143-2/abstract
- Lledo W et al
Guidance for Control of Infections with Carbapenem-Resistant
or Carbapenemase-Producing Enterobacteriaceae in Acute Care
Facilities
MMWR 2009 58(10);256-260
http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5810a4.htm
- Morbidity and Mortality Weekly Report (MMWR)
Detection of Enterobacteriaceae Isolates Carrying Metallo-
Beta-Lactamase --- United States, 2010
June 25, 2010 / 59(24);750
PMID: 20577157
http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5924a5.htm